BDBM50200383 CHEMBL3938408::US9763922, Example 73

SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1ccnn1C)nn2CC1CC1

InChI Key InChIKey=HLTFLEHNLNKZIT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50200383   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200383(CHEMBL3938408 | US9763922, Example 73)
Affinity DataIC50:  3.70E+3nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRD4 bromodomain-1 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50200383(CHEMBL3938408 | US9763922, Example 73)
Affinity DataIC50:  3.05E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In DepthDetails US Patent